What is Letrozole? Dosage | Side effects | Letrozole for Men and Women

After reading this article, you will be able to clarify all your doubts regarding Letrozole, when, by whom, and how to use and many more.

Letrozole

Letrozole is used as a drug for curing postmenopausal women suffering from breast cancer caused by the circulation of estrogen in the blood. It inhibits enzymes in adrenal glands which produce estrogen. Therefore helps to prevent cancer from further returning.

This is a very sensitive drug and is highly effective but still good for all the uses. Not only for breast cancer but it has many wide aspects you can further.

Scientific Elaboration

Letrozole or Bis(4-cyanophenyl)methanol and 4,4′-dicyanobenzophenone having chemical formula C17H11N5 and molar mass equal to 285.31 gram per mole is sold under the brand name Femara. This comes under the class of aromatase inhibitors. It exists as solid and is non-solvent too. It was approved by the US Food and Drug Administration in 1997.

Why is Letrozole Prescribed?

It is prescribed to women, when they experience Menopause during breast cancer treatment and who have been through other treatments, such as radiation or surgery for tumor removal. Not only in women it is also prescribed to increase testosterone in men.

Letrozole is preferable to deal with any kind of impotency in any gender.

According to a research, Of the 374 ladies who got letrozole, 103 (27.5 percent) in the end had a live birth Of the 376 ladies who got clomiphene, 72 (19.1 percent) encountered a live birth The combined ovulation rate was higher for the letrozole gathering, with ovulation happening multiple times in 1352 cycles or 61.7 percent of the time.

As per the 2015 Canadian research, the letrozole pill restores fertility in men with obesity. 

Letrozole for men

It increases mobility and sperm count whereas reduces estrogen hormone in men which is responsible for degrading sperm quality and manifesting breast development.

There was a survey held where 12 infertile men were given 2.5-milligram letrozole and it worked well on increasing sperm count but only two pregnancies were successful and 3 couples conceived using In Vitro Fertilization method.

Letrozole is additionally used by bodybuilders when they consume anabolic steroids. Well neither of us should rely on synthetic chemicals for treatment.

The alternative of letrozole pills can be.

  1. Protein, carbohydrate-rich diet, and the food can also contain little unsaturated fat.
  2. Involving exercise is a daily routine. 
  3. Take vitamins and minerals.
  4. Refrain from stressing and remain positive. 
  5. Take the proper 8 hr sleep.

Letrozole for women

Letrozole for females is given to women who have been taking tamoxifen (Nolvadex, Soltamox) for 5 years.

It increases ovulation in women with PCOS

In a 2014 study from the New England Journal of Medicine, women with PCOS who took letrozole, 27.5% of women faced chances of pregnancy.

Women ovulate after 5 to 8 days of letrozole consumption.

Femara when used for breast cancer treatment is only for menopausal women.

It also causes vaginal bleeding for wannabe pregnant women but doesn’t affect periods. Periods due to letrozole can still be delayed by 5 to 6 days.

However successful ovulation can result in no period.

Letrozole lowers estrogen level which increases the Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) hormone to stimulate eggs to mature and release by ovaries.

An alternative to letrozole pill in the case of women can be

  1. Avoiding trans fats.
  2. By eating fewer refined carbohydrates.
  3. By consuming breakfast in a very large amount.
  4. By focusing on eating dairy products.
  5. Women are not supposed to drink or smoke to increase ovulation.

How to Take letrozole?

In case of increasing fertility, letrozole should be consumed by taking two tablets of 2.5 milligrams daily from the 3rd day of the beginning of the menstruation cycle till day seven.

You can take that medicine any time of the day and it doesn’t matter if you have eaten something or not. Make sure to give an exact 12-hour gap between every pill.

This medicine must be used only under Pharmaceutical supervision. Ensure you have no allergy because of its chemical composition or due to any medicine. Tell your doctor if you have high cholesterol, osteoporosis, or any liver disease.

Accept that you missed a portion when you realize. Be that as it may, skip the missed portion and proceed with your customary dosing plan. Try not to take a twofold portion to compensate for a missed one.

Letrozole can make you clumsy and drowsy so make a note of that and don’t indulge in a high amount of work.

Side effects of Letrozole

Letrozole may cause negative results. Tell your PCP if any of these side effects are serious or don’t disappear:

  • hot flushes 
  • night sweats 
  • queasiness 
  • spewing 
  • loss of craving 
  • obstruction 
  • looseness of the bowels 
  • indigestion 
  •  stomach cramps
  • changes in weight 
  • extreme sluggishness 
  • cerebral pain 
  • wooziness 
  • shortcoming 
  • swelling of the hands, feet, lower legs, or lower legs 
  • trouble nodding off or staying unconscious 
  • vaginal bleeding or disturbance 
  • chest pain
  • hair loss
  • hazy vision

In addition to this, Letrozole can also cause a reduction in bone density, uncanny stress, yellowing of the skin or eyes.

Letrozole can increase the amount of fat or cholesterol in the blood which can result in weight gaining. Many women gained some amount of weight during the treatment of breast cancer and few of them made aromatase inhibitors responsible for this. Weight gained by this method is also hard to lose. Overweighting of the body can also decrease the chances of ovulation, then pregnancy.

Things to be kept in mind.

  1. Take letrozole after food. It is good and prevents nausea.
  2. Avoid taking anastrozole or tamoxifen as it can react with letrozole and produce contraindication.
  3. Always listen to the doctor’s advice. Do not start or stop medicine before seeking their referral.
  4. Never take nicotine, alcohol, caffeine when you are taking letrozole.
  5. It is generally taken for 5 to 10 years only.

The alternative to this drug is anastrozole and tamoxifen.

Precaution

Every human may have a different prescription. Do not share your prescription with anyone.

Research centers as well as clinical tests, (for example, bone thickness tests, cholesterol levels, liver capacity tests) ought to be performed occasionally to screen your advancement or check for results. Counsel your primary care physician for additional subtleties. 

Store at room temperature away from light and dampness. Try not to store in the washroom. Get all prescriptions far from kids and pets. 

Try not to flush prescriptions down or empty them into a channel except if taught to do as such. Appropriately dispose of this item when it has lapsed or not, at this point required. Counsel your drug specialist.

Also Read: Can Dogs Eat Tomatoes?

Conclusion

Looks like we have far more known everything about Letrozole including all the data listed above. Just take the right amount with proper consultancy and you will be able to get the best of it with fewer side effects.

FAQs

Can I take letrozole at 20 years of age?

No, at 20 years of age you are not supposed to consume this drug because you will harm yourself. At this certain age, you will have a variety of options for your treatment. The minimum consumption age of letrozole is near 40.

As a boy, if I am developing breasts, how will letrozole help me?

Letrozole can help you in decreasing estrogen hormone which is responsible for breast development but there are certain consequences you may face but take this.

Can letrozole cause memory loss?

It can indeed cause malfunctioning of neurons in the part of the brain. It cannot be responsible for memory loss but can harm your brain if taken more than the prescribed amount.

Is letrozole used for chemotherapy?

Letrozole can be used for oral chemotherapy when a person can take this drug through their mouth.

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